![]() In Salmonella, there are five types of QS signal molecules that contribute to the regulation of bacterial survival and virulence. Different Signal Molecules Mediate QS in Salmonella Such a strategy may have the potential to be a promising next-generation therapy to control Salmonella infection and tackle the development of antibiotic resistance. In this article, we described the formation of different QS in Salmonella, discussed regulatory mechanisms between QS and Salmonella virulence, and focused on a new strategy for using the QS system to combat Salmonella infection. Consequently, inhibition of Salmonella QS has become a new and promising antibacterial strategy, which not only resists Salmonella virulence but also prevents the development of bacterial resistance. The cellular processes are associated with bacterial virulence and survival of bacteria in their environment, such as biofilm formation, flagellar-mediated motility, adhesion and invasion, andT3SS. QS affects the biosynthesis and assembly of pef fimbria by regulating the expression of Salmonella (the resistance to complement killing) rck locus. With a threshold concentration of QS molecules reached, the receptor protein interacts with the QS molecules which induces a signaling pathway that consequently modulates cellular metabolic processes in response to environmental changes. Many bacteria can produce and release QS molecules into the environment, which allows bacteria to respond to their own and environmental conditions by receiving signal molecules from the environment and themselves. The quorum sensing (QS) system is an intercellular cell–cell communication mechanism that coordinates bacterial adaptation to the environment. Unraveling the complex relationship between QS and bacterial virulence may provide new insight into the therapy of pathogen infection. ![]() Here, we have reviewed the central role of the QS system in virulence regulation of Salmonella and summarized the most recent advances about quorum quenching (QQ) in virulence attenuation during Salmonella infection. Therefore, blocking the QS system may be a new strategy for Salmonella infection independent of antibiotic treatment. Bacterial quorum sensing (QS) system is an intercellular cell–cell communication mechanism involving multiple cellular processes, especially bacterial virulence, such as biofilm formation, motility, adherence, and invasion. However, the prevention and treatment of Salmonella infection has remained poorly developed because of its antibiotic resistance. Salmonella is a foodborne pathogen that causes enterogastritis among humans, livestock and poultry, and it not only causes huge economic losses for the feed industry but also endangers public health around the world. ![]()
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